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Analysis of potential drug-drug interactions in the intensive care unit using healthcare claims database and drug information database
Journal of the Korean Data & Information Science Society 2018;29:1543-53
Published online November 30, 2018
© 2018 Korean Data and Information Science Society.

Jisu Lee1 · Jisu Lee2 · Ilsang Ohn3 · Yongdai Kim4

1Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital and Seoul National University College of Medicine
2Department of statistics, Sungkyunkwan University
34College of Pharmacy, Chung-Ang University
Correspondence to: Assistant professor, College of Pharmacy, Chung-Ang University, 84 Heukseokro, Dongjak-gu, Seoul 06974, Korea. E-mail:
This research was partially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant no. NRF-2017R1D1A1B03032231).
Received October 2, 2018; Revised November 14, 2018; Accepted November 14, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A drug-drug interaction occurs when two or more drugs interact with each other; this can clinically result in adverse drug events with changes in drug effects. This study aimed to analyze prevalence of polypharmacy and potential drug-drug interactions (pDDI) with opioid analgesics in geriatric patients in the intensive care unit using claims data. We used the aged patients’ sample for 2016 and Micromedex as the drug information database in this analysis. Among 1,327,455 patients, we selected 20,050 patients who were prescribed opioids in the intensive care unit. Mean age was 76.4 years and median ICU stay was 3 days. Among the 20,050 patients, prevalence of co-prescription was 91.1%; median number of drugs prescribed per patient was 3 (range, 0-25). The prevalence of pDDI between opioids and other drugs was 54.3%. Multiple logistic regression showed that pDDI was related to surgery, number of drugs prescribed, age, and admission through emergency room.
Keywords : Aged, drug-drug interactions, intensive care unit, logistic regression model, opioid analgesics.